WSSmod - Weighted Sum Scores for Protein Network Modules

Computes Weighted Sum Score (WSS) module-level summaries from proteomic data. Protein-level values are sign-aligned to their association with core biomarkers and combined within 'STRING' network modules, weighted by network connectivity and association strength. Bundled reference modules and a fitted 'joinet' model also allow all module scores to be predicted from age, sex and a small panel of plasma biomarkers, without measuring the full proteomic panel. The method is described in Butler et al. (2026) <doi:10.64898/2026.08.14.26360394>.